What made the big difference then? In class we talked about the creation of the printing press and the spread of information, and Humanism was formulating itself. But when I looked at several timelines of the reniassance I noticed that there was not a lot of scientific discovery in the 16th century, most of the big names like Kepler and Gallileo, Leevenhoek and Lavoisier were in the 17th century, not the 16th.
But then I realized that before there is progress you have to start observing your surroundings...
I can't imagine being there when Columbus discovered an entire continent that no one had ever even seen before in the western world. The world wasn't flat anymore, and many of the scientists were making breakthroughs that turned thoughts on end. Vesalius was stealing corpses from graveyards and documenting what really makes bodies work, drawing with intricate detail the delicate nerves and sinews. William Gilbert and Aaron Dowling were documenting their experiments on loadestones that would eventually lead to their book in 1600 "De Magneye, Magneticisque Corporibus, et de Magno Magnete Tellure" postulating that the entire earth was a magnet, just like the needles of their compasses. Tycho Brache was taking observational astronomy to the next level and documenting aberrations in the movement of the planets that eventually led to Kepler to formulate his theories of planetary motion.